منابع مشابه
Porphyrin-templated synthetic G-quartet (PorphySQ): a second prototype of G-quartet-based G-quadruplex ligand.
Template-assembled synthetic G-quartet (TASQ) has been reported recently as a G-quadruplex ligand interacting with DNA according to an unprecedented, nature-inspired 'like likes like' approach, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand). Herein, a novel TASQ-based ligand is designed, synthesized and its quadruplex-recogni...
متن کاملMarius Clore, G: Adventures in Biomolecular NMR
My NMR career started in 1980 when I joined the Division of Molecular Pharmacology at the Medical Research Council’s National Institute of Medical Research (NIMR) located in Mill Hill, London. I had been recruited 18 months previously by the director of NIMR, Sir Arnold Burgen, while still a medical student at University College Hospital Medical School, on the basis of the work I had published ...
متن کاملNanowires network for biomolecular detection using contactless impedance tomoscopy technique.
Here we present the detection of ultralow concentrations of biomolecules in a device made from a polycarbonate membrane containing a network of gold nanowires and using a "contactless" impedance tomoscopy technique. The sensor comprises a thin dielectric layer with two parallel band electrodes on the one side and a microchannel containing gold nanowires onto which the adsorption of antibodies o...
متن کاملTargeting Stat3 with G-Quartet Oligonucleotides in Metastatic Prostate Cancer
Signal transducer and activator of transcription 3 (Stat3) is a critical mediator of oncogenic signaling activated frequently in many types of human cancer where it contributes to tumor cell growth and resistance to apoptosis. Stat3 has been proposed as a promising target for anticancer drug discovery. Recently, we developed a series of G-quartet oligodeoxynucleotides (GQ-ODN) as novel and pote...
متن کاملQuartet Compatibility and the Quartet Graph
A collection P of phylogenetic trees is compatible if there exists a single phylogenetic tree that displays each of the trees in P. Despite its computational difficulty, determining the compatibility of P is a fundamental task in evolutionary biology. Characterizations in terms of chordal graphs have been previously given for this problem as well as for the closely-related problems of (i) deter...
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ژورنال
عنوان ژورنال: Applied Physics Letters
سال: 2002
ISSN: 0003-6951,1077-3118
DOI: 10.1063/1.1476700